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2007, to start with genuine-time detection of strand exchange in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping
Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
Since 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his exploration has focused on studying mobile division with microorganisms on chip, whilst his ultimate fascination is inside the way of noticing synthetic cells.
Atomic drive microscopy shows that vaccinia topoisomerase IB ceesdekker.net generates filaments on DNA in the cooperative manner
Being familiar with essential procedures regulating the spatial and dynamic organisation of your DNA in Are living cells.
Pretty great, but that wasn’t definitely exactly where my fascination lay. I needed to pioneer and I had the sensation which was no longer attainable, as the most interesting basic insights experienced now been uncovered. But my area had created quite a few thrilling new instruments to evaluate particular person molecules. I decided that I desired to use this to biology, to take a look at it from a physical perspective.’
Screening pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Character Physics thanks the nameless reviewers for their contribution on the peer assessment of the operate.
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2013, managed shaping of Dwell bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes